منابع مشابه
Lithium augmentation in antidepressant-resistant patients.
SIR: Austin et a! (Journal, October 1991, 159, 510— 514) recently presentedtheir meta-analysisof five placebo-controlled trials oflithium augmentation in depressed patients “¿ resistant to a standard trial of an antidepressant―. They concluded that lithium aug mentation had significant efficacy in these patients. However, as the authors acknowledged, while the statistical procedure used t...
متن کاملBrief Communication Lithium and Triiodothyronine Augmentation of Antidepressants
There are now sufficient data to suggest that lithium is an effective augmentation strategy for patients with major depression who have an inadequate response to all classes of antidepressants (1). A recent metaanalysis supports the efficacy of T3 in treatment-resistant depression (2); these studies involving T3 were in patients taking tricyclic antidepressants, although a recent study supports...
متن کاملAccelerated antidepressant response to lithium augmentation of imipramine
BACKGROUND Treatment of depressive episode often poses a challenge. Although there are numerous medicines available for its treatment but they all have a lag period of 2-3 weeks before they start showing their result. AIM The aim of the present study was to test the hypothesis that an initial lithium-tricyclic antidepressant (TCA) combination has a quicker and better antidepressant effect tha...
متن کاملLithium augmentation of nortriptyline for subjects resistant to multiple antidepressants.
Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who also failed a prospective trial of nortriptyline. We enrolled 92 subjects with t...
متن کاملLithium augmentation therapy in refractory depression: clinical evidence and neurobiological mechanisms.
OBJECTIVE This systematic review examines the evidence and discusses the clinical relevance of lithium augmentation as a treatment strategy for refractory major depressive episodes. It also examines hypotheses on the mode of action of lithium augmentation, with a focus on serotonin (5-HT) and neuroendocrine systems, and proposes recommendations for future research. METHOD We searched the Medl...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1995
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.166.5.679a